"Work factors: high demands, increasing responsibilities, insecurity, uncertainty about progress" "Family factors: increased care demands for children and older relatives, role and structural changes" "Physical health: decline in physical health, unhealthy behaviours, increased distress" "Social factors: loneliness, lack of time for hobbies, social capital" "Adverse events: divorce, poor socioeconomic circumstances" "Early life factors: general vulnerability to distress (e.g. low cognitive scores, poor child mental health, poor academic achievement, parental death and family characteristics)" "Personality and identity (e.g. neuroticism, identity confusion, unmet expectations)"