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Research Idea
Research Ideas and Outcomes 10: e107983
https://doi.org/10.3897/rio.10.e107983 (13 May 2024)
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  • ContentsContents
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  • Project Aims
  • Literature Review for Proposal Justification
    • Adaptability of Homo neanderthalensis
      • Neanderthal Cold Adaptation
      • Navigating Alternate Explanations
    • The Haemoglobin Molecule
      • Human Globin Genes
      • Haemoglobin Function and Cold
      • Adaptability of the Haemoglobin Molecule
    • Resurrection of Extinct Molecules
      • Current Methodologies in Ancient DNA Work
      • Expressing Extinct Gene Products
      • Detecting Positive Directional Selection
    • Anthropological De-Extinction
  • Proposed Materials and Methods
    • Data Acquisition
      • Ethical Considerations
    • Identification of Neanderthal Globin Genes
    • DNA Sequence Comparisons
    • Identifying Natural Selection
      • Statistical Methodologies
      • Structure-Function Analyses
    • Expressing Extinct Proteins
    • Molecular Function Analysis
    • Identifying Structural Bases for Functional Differences
  • Acknowledgements
  • References
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