Research Ideas and Outcomes : Single-media Publication
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Corresponding author: Robert Jeenchen Chen (rjcc@ntu.edu.tw)
Received: 20 Jun 2016 | Published: 27 Jun 2016
© 2016 Robert Jeenchen Chen, Wei-hsuan Yu.
This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Citation: Chen R, Yu W (2016) Matrix Proteins and Proteinases Network in Human Cardiovascular Diseases Explored By Cytoscape. Research Ideas and Outcomes 2: e9617. doi: 10.3897/rio.2.e9617
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Matrix proteins and proteinases altered extracellular matrix that involves in various pathogenesis of cardiovascular diseases. Systematic review selected matrix metalloproteinase-7 (MMP7), a disintegrin and metalloproteinase-17 (ADAM17), type I collagen (COL1), syndecan (SDC), and versican (VCAN). Their network was drawn by Cytoscape and Agilent Literature Search. MMP7, ADAM17, and SDC were grouped together. VCAN and COL1 had inadequate evidence to connect their human potential networks that were more evidence in animal models. The findings may provide clues for further laboratory investigations.
Cytoscape, matrix proteins, metalloproteinase, network, cardiac disease
As the extracellular matrix (ECM) plays pivotal roles in regulating cardiac structural and functional integrity (
Thorough systematic review was by using PubMed search. On Cytoscape 3.40 (http://www.cytoscape.org), we used Agilent Literature Search 3.11 to explore the molecular relationships. For the extraction control, the concept lexicon was “Homo sapiens”, and the interaction lexicon was set to “limited”. The network was drawn with GeneMANIA Force Directed layout. We screened most of the molecules available from systematic review and selected the most relevant ones for subsequent Cytoscape analysis.
Systematic reviews with PubMed.
Online public-domain databases used by Cytoscape.
From all the known and potential molecules relating to cardiovascular disease such as cardiomyopathy and transplant allograft rejection (
Cytoscape network shows the interplaying roles of MMP7, ADAM17, SDC, COL1, and VCAN in the pathogenesis of cardiovascular diseases like cardiomyopathy and transplant rejection have been implied by the Cytoscape exploration. Further human laboratory experiments will be done to investigate the theoretical network.
American Heart Association's Scientific Sessions 2016, November 12-16, New Orleans, Louisiana.
National Taiwan University College of Medicine, Taipei, Taiwan
Waived Institutional Review Board (IRB) review.
Chen RJC: concept, study design, analysis, and manuscripting; Yu WH: concept, revision, and supersion.